The evolution of transcriptional regulators through the recruitment of DNA-binding domains by enzymes is a widely held notion.However, few experimental approaches have directly addressed this hypothesis.Here we report the reconstruction of a plausible pathway for the evolution of an enzyme into a transcriptional regulator.The BzdR protein is Bundle

Melodic harmonisation is a sophisticated creative process that involves deep musical understanding and a specialised knowledge of music relating to melodic structure, harmony, rhythm, texture, and form.In this article a new melodic harmonisation assistant is presented that is adaptive (learns from data), general (can cope with any tonal or non-tona

New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions.The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain.However, a prior study identified elevated Filters tumor necrosis factor alpha within the